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Department of Pharmacology, Toxicology, and Therapeutics

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Principal Course Distribution Requirement

Principal courses offer introductions to the breadth of disciplines in the College. They acquaint students with the subject matter in an area, with the types of questions that are asked about that subject matter, with the knowledge that has been developed and is now basic to the area, and with the methods and standards by which claims to truth are judged.

Students must complete courses in topical groups in three major divisions (humanities, natural sciences and mathematics, and social sciences). For the B.A., three courses are required from each division, with no more than one course from any topical group. The B.G.S. requires two courses from each division, with no more than one from any topical group. To fulfill the requirement, a course must be designated as a principal course according to the codes listed below.

These are the major divisions, their topical subgroups, and the codes that identify them:

Humanities

  • HT: Historical studies
  • HL: Literature and the arts
  • HR: Philosophy and religion

Natural Sciences and Mathematics

  • NB: Biological sciences
  • NE: Earth sciences
  • NM: Mathematical sciences
  • NP: Physical science

Social Sciences

  • SC: Culture and society
  • SI: Individual behavior
  • SF: Public affairs

No course may fulfill both a principal course distribution requirement and a non-Western culture or second-level mathematics course requirement. Laboratory science courses designated as principal courses may fulfill both the laboratory science requirement and one of the distribution requirements. No free-standing laboratory course may by itself fulfill either the laboratory science requirement or a principal course requirement. Students should begin taking principal courses early in their academic careers. An honors equivalent of a principal course may fulfill a principal course requirement.

View all approved principal course distribution courses »

Non-Western Culture Requirement

A non-Western culture course acquaints students with the culture, society, and values of a non-Western people, for example, from Asia, the Pacific Islands, the Middle East, or Africa. Students must complete one approved non-Western culture course.

One approved non-Western culture course is required. Occasionally courses with varying topics fulfill the non-Western culture course requirement. See the Schedule of Classes for details. These courses are coded NW.

View all approved non-Western culture courses »

Transfer and Earned Credit Course Codes

These codes are used to evaluate transfer credit and to determine which academic requirements a course meets.

  • H: Humanities
  • N: Natural Sciences and Mathematics
  • S: Social Sciences
  • W: World Civilization and Culture
  • U: Undesignated Elective Credit (course does not satisfy distribution requirement)

All Pharmacology, Toxicology, and Therapeutics courses

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General principles of pharmacology, including pharmacokinetics, pharmacodynamics, adverse effects, pharmacotherapeutics plus miscellaneous agents (antacids, cathartics, biologicals). Open to advanced B.S. students and graduate students in Nursing, Allied Health, and other health related programs. Independent study program with use of computer assisted instruction, textbooks, syllabi, consultation with staff and exams as primary teaching instruments. Students are encouraged to complete this course the semester they enroll. If this course is not completed, students will receive an Incomplete grade. Prerequisite: An Enrollment Permission Form must be signed by the student and the instructor. In addition, the enrollment card must be stamped by the instructor. LEC
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General principles of the autonomic nervous system, cholinergics, muscarinics, nicotinics, neuromuscular blockers, beta adrenergics, alpha adrenergics, and miscellaneous ANS agents. Students are encouraged to complete this course the semester they enroll. If this course is not completed, students will receive an incomplete grade. Prerequisite: PHCL 761 and an Enrollment Permission Form must be signed by the student and the instructor. In addition, the enrollment card must be stamped by the instructor. LEC
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Antihypertensives, antiarrhythmics, vasodilators, cardiac glycosides, serotonin, histamine, polypeptides, diuretics, antilipidemics. Students are encouraged to complete this course the semester they enroll. If this course is not completed, students will receive an incomplete grade. Prerequisite: PHCL 761 and an Enrollment Permission Form must be signed by the student and the instructor. In addition, the enrollment card must be stamped by the instructor. LEC
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General principles of the central nervous system, stimulants, hallucinogens, depressants (hypnotics and sedatives), general and local anesthesia, antiparkinson agents, tranquilizers, analgesics and anticonvulsants. Students are encouraged to complete this course the semester they enroll. If this course is not completed, students will receive an Incomplete grade. Prerequisite: PHCL 761 and an Enrollment Permission Form must be signed by the student and the instructor. In addition, the enrollment card must be stamped by the instructor. LEC
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Principles of chemotherapy, sulfonamides, penicillins, aminoglycosides, anticancer and antifungal agents, antimalarials, broad spectrum antibiotics, antiparasitic agents, and antiseptics. Students are encouraged to complete this course the semester they enroll. If this course is not completed, students will receive an Incomplete grade. Prerequisite: PHCL 761 and an Enrollment Permission Form must be signed by the student and the instructor. In addition, the enrollment card must be stamped by the instructor. LEC
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General principles of endocrine function and use, thyroid drugs, insulin, sex hormones, oxytocics, adrenal steroids, antiinflammatory agents, blood drugs, anticoagulants and vitamins. Students are encouraged to complete this course the semester they enroll. If this course is not completed, students will receive an incomplete grade. Prerequisite: PHCL 761 and an Enrollment Permission Form must be signed by the student and the instructor. In addition, the enrollment card must be stamped by the instructor. LEC
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General principles of toxicology, clinical toxicology, solvents, metals, gases and dusts, corrosives, plant and animal toxins, pesticides, radiation, miscellaneous. Students are encouraged to complete this course the semester they enroll. If this course is not completed, students will receive an incomplete grade. Prerequisite: PHCL 761 and an Enrollment Permission Form must be signed by the student and the instructor. In addition, the enrollment card must be stamped by the instructor. LEC
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Weekly meetings. LEC
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A discussion dealing with the literature and history of pharmacology. The development of the British school, German school and the origin of American pharmacology are emphasized. LEC
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Molecular foundations of drug action, including chemical structure of drugs, kinetics and consequences of drug-receptor interactions, and methods for characterizing receptors, and receptor-mediated events. Prerequisite: Permission of course director. LEC
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Team taught, in-depth neuroscience course focusing on normal and diseased brain function at the molecular, cellular and systems levels. Lectures and discussions will emphasize current issues in neuroscience research. (Same as ANAT 846, PHSL 846 and NURO 846). Prerequisite: Permission of course director. LEC
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An in-depth coverage of pathogenic mechanisms in neurological diseases; cellular and molecular responses to brain injury and disease, neuroinflammatory diseases (e.g., multiple sclerosis), neurodegenerative diseases (e.g., Alzheimer's, Parkinson's, Huntington's, amyotrophic lateral sclerosis, and prion diseases), neurogenetic diseases (e.g., lysosomal and peroxisomal disorders, Down's syndrome and fragile X), trauma, stroke, and viral diseases (e.g., HIV encephalitis). (Same as ANAT 848, NURO 848, and PHSL 848.) Prerequisite: Advanced Neuroscience (ANAT 846, PHCL 846 or PHSL 846) or an equivalent course and consent of instructor. LEC
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Introduction to Pharmacology for Graduate Students. Autonomic, Cardiovascular and Renal, Endocrine, Neuro, Antivirals Pharmacology. Autacoids; Workshop; Historical and Contemporary Methods used to Elucidate Mechanisms of Drug Action. Prerequisite: Successful completion of the Interdisciplinary Program in Biomedical Sciences or permission of the Instructor. LEC
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General principles of pharmacology, including pharmacokinetics, pharmacodynamics, adverse effects, pharmacotherapeutics, plus miscellaneous agents (antacids, cathartics). Open to graduate students in Nursing, Allied Health, and other health related programs with adequate backgrounds in physiology and biochemistry. Independent study program with use of computer assisted instruction, textbooks, syllabi, consultation with staff and exams as primary teaching instruments. Prerequisite: Permission of department. LEC
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General principles of the autonomic nervous system, cholinergics, muscarinics, nicotinics, neuromuscular blockers, beta adrenergics, alpha adrenergics and miscellaneous ANS agents. Prerequisite: PHCL 881 and permission of department. LEC
View current sections...
Antihypertensive drugs, antiarrhythmics, vasodilators, cardiac glycosides, serotonin, histamine, polypeptides, diuretics, antilipidemics. Prerequisite: PHCL 881 and permission of department. LEC
View current sections...
General principles of the central nervous system, stimulants, hallucinogens, depressants (hypnotics and sedatives), general and local anesthesia, antiparkinson agents, tranquilizers, analgesics and anticonvulsants. Prerequisite: PHCL 881 and permission of department. LEC
View current sections...
Principles of chemotherapy, sulfonamides, penicillins, aminoglycosides, anticancer agents, antifungal agents, antimalarials, broad spectrum antibiotics, antiparasitic agents, and antiseptics. Prerequisite: PHCL 881 and permission of department. LEC
View current sections...
General principles of endocrine function and use, thyroid drugs, insulin, sex hormones, oxytocics, adrenal steroids, antiinflammatory agents, blood drugs, anticoagulants and vitamins. Prerequisite: PHCL 881 and permission of department. LEC
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General principles of toxicology, clinical toxicology, solvents, metals, gases and dusts, corrosives, plant and animal toxins, pesticides, radiation, miscellaneous. Prerequisite: PHCL 881 and permission of department. LEC
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Pharmacology covers the following topics: establishment of rational pharmacological basis for drug therapy; physiological and biochemical effects of drugs and foreign compounds on biological systems; mechanisms responsible for the therapeutic and toxic effects, uses, and disadvantages of drugs. Prerequisite: Consent of instructor. LEC
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For graduate students beginning their research training. RSH
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Chemical fundamentals in structure, actions and metabolism of drugs and toxicants. Included are molecular features of drugs and toxicants, steroisomerism, receptor theory, dose-response relationships, agonists and anatgonists, absorption, pharmacokinetics and structure-activity relationships. LEC
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For students in a master's program in pharmacology. THE
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A laboratory course designed to acquaint the student with research methods in a number of specific areas in pharmacology. LAB
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Physical, chemical, and stereochemical aspects of drug action. Includes discussions of receptor theory, methods used in receptor studies and drug design. Prerequisite: PHCL 888 or permission from the Department of Pharmacology. LEC
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Principles of nerve transmission. Emphasis is placed on the central nervous system. Includes a discussion of the neurochemical aspects. Prerequisite: PHCL 888 or permission from the Department of Pharmacology. LEC
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Action of drugs on the heart and vascular system. Emphasis will be placed on physiological and biochemical mechanisms of drug action. Prerequisite: PHCL 888 or departmental permission. LEC
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Designed to acquaint students with the actions of drugs on neogenesis and manifestation of the immune response. Drug effects on T and B lymphocytes. Anti-inflammatory drugs. Prerequisite: PHCL 888 or departmental permission. LEC
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Discussion of drug effects on physiological homeostatic mechanisms. Includes hormones, polypeptides, histamine, serotonin, acetylcholine, catecholamines, and kinins. Prerequisite: PHCL 888 or departmental permission. LEC
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Drug action on cells and subcellular organelles. Drug effects on nucleic acid synthesis, protein synthesis, and cell adhesion. Drug effects on tissue cultures. Prerequisite: PHCL 888 or departmental permission. LEC
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Designed to give practical and theoretical experience with drug trials in humans. Includes animal experimentation when warranted. Clinical principles of drug therapy will be emphasized. IND
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Multidisciplinary approach. Cancer pathology. Mutagenesis, Genetics, Carcinogen metabolism. Signal Transduction, Apoptosis, Initiation and promotion. Tumor Immunology. Cell proliferation. Protooncogenes and suppressor genes. Hormonal carcinogenesis. Cancer epidemiology. Dietary and environmental causation and prevention. Cancer in various organ systems. (Same as PATH 939 and PTOX 939.) Prerequisite: Completion of one of the following: IGPBS modules 1-4 or equivalent or permission of instructor. LEC
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Principles of basic, peripheral and central nervous system pharmacology and topics in immunopharmacology and neuroimmunopharmacology. Prerequisite: PHCL 841 or permission of course director. LEC
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Pharmacological principles of drug actions on the endocrine and cardiovascular systems. This includes the effects of drugs on the interactions of hormones and autocoids with the cardiovascular system. Prerequisite: PHCL 841 or permission of Course Director. LEC
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Prerequisite: PHCL 890. RSH
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Prerequisite: Open to students of advanced standing enrolled in the doctoral program in Pharmacology. THE
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Instruct students in developmental steps used in translating a basic science experiment with clinical applications into a proof of concept application and human trial. Multidisciplinary approach; lectures from faculty in Pharmacology, KU Cancer Ctr, KUMCRI. Curriculum: Levels of evidence-clinical impact, Pre-Clinical modeling, In-Vitro studies & Animal models, Cancer Drug Development-pharmacokinetics & toxicity, Pre-Clinical Proof of Concept & FDA, Creating a Pilot Study, Biostatistics 101, Phases of Clinical Trials, Data Collection, Support Staff, Regulatory and DSMBs, IRB and HIPPA, Funding Study: Grants & Parma, Advertising study & meeting accrual goals, Goals of Phase I study, Goals & Objectives of Phase II Efficacy study, Phase 3 Multicenter Study: Value of Numbers & Utilizing Cooperative Groups. Prerequisite: Completion of first 2 years of Med School or graduate school, or enrollment in MD/PhD program. Students no meeting one of these criteria will require permission from course instructor. LEC
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Molecular foundations of chemical action, including structure of chemicals, kinetics and consequences of chemical-receptor interactions, and methods for characterizing receptors, and receptor-mediated events. Prerequisite: Permission of course director. LEC
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Introductory pathology course for graduate students preparing for a career in basic toxicology research. Topics to be presented and discussed include: cell injury, inflammation, repair and regeneration, immunopathology, neoplasia, tumor pathology, respiratory pathology, liver pathology, neuropathology, miscellaneous organ pathology, and lab animal clinical chemistry. LEC
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Introductory pathology course for planning on being research toxicologists. Topics to be presented and discussed: cell injury, inflammation, repair and regeneration, immunopath, neoplasia, tumor pathology, respiratory pathology, liver pathology, neuropathology, miscellaneous organ pathology, and lab animal clinical chemistry. LEC
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Chemical fundamentals in structure, actions and metabolism of toxicants and drugs. Included are molecular features of toxicants and drugs, stereoisomerism, receptor theory, dose-response relationships, agonists and antagonists, absorption, pharmacokinetics, and structure-activity relationships. LEC
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For students in a master's program in toxicology. THE
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Principles of absorption, biotransformation, and excretion of xenobiotics. Prerequisite: PHCL 888 or departmental permission. LEC
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Selected topics in environmental, forensic, and industrial toxicology. LEC
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Detailed discussion of the pharmacokinetics of chemicals and drugs; discussion of the p-450 system, its influence on the biological half-life and toxicity of xenobiotics. Prerequisite: PTOX 917 or departmental permission. LEC
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Individualized discussions dealing with the toxicity of xenobiotics. Subjects to be discussed are the mechanisms of toxic action of pesticides, solvents, metals, radiation, gases, and plant and animal toxins. Prerequisite: PTOX 918 or departmental permission. LEC
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Multidisciplinary approach. Cancer pathology. Mutagenesis. Genetics. Carcinogen metabolism. Signal Transduction, Apoptosis. Initiation and promotion. Tumor immunology. Cell proliferation. Protooncogenes and suppressor genes. Hormonal carcinogenesis. Cancer epidemiology. Angiogenesis. Dietary and environmental causation and prevention. Cancer in various organ systems. (Same as PATH 939 and PHCL 939.) Prerequisite: Completion of one of the following: IGPBS modules 1-4 or equivalent or permission of instructor. LEC
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A unique course where students are exposed to and have practical experience in techniques used for risk-assessment of chemicals. The course is taught with extensive input by industrial toxicologists who use these techniques on a daily basis. This course is offered at a local industrial setting. Prerequisite: PHCL 888; PTOX 917, PTOX 918, and PTOX 938, or departmental permission. LEC
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Prerequisite: PTOX 889. RSH
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Prerequisite: Open to students of advanced standing enrolled in the doctoral program in toxicology. THE
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