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Department of Medicinal Chemistry

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Facilities

The department is well equipped for both chemical and biochemical research and has research facilities for about 70 graduate students, postdoctoral associates, and research technicians. Malott Hall, where most of the medicinal chemistry laboratories are located, also houses the departments of Chemistry and Pharmacology and Toxicology. Anschutz Library is adjacent to the building. Much of the laboratory space in the department has recently undergone renovation and provides exceptional research laboratories for chemical synthesis and biochemical research. The department has an excellent complement of modern spectroscopic, biochemical, and chromatographic instrumentation, and other specialized research instrumentation is available through cooperative arrangements with other departments.

Advanced instrumentation and facilities are available through KU’s Molecular Structures Group. MSG laboratories include the Biochemical Research Service Laboratory, the Mass Spectrometry Laboratory, the Nuclear Magnetic Resonance Laboratory, the Molecular Graphics and Modeling Laboratory, the X-ray Crystallography Laboratory, and the Protein Structure Laboratory (dedicated to macromolecular X-ray crystallography) with more than $10 million in instrumentation.

The Shankel Structural Biology Center, on KU’s west campus, offers new research opportunities for medicinal chemists interested in protein and nucleic acid structure and combinatorial synthesis; it also houses the new 800-MHz NMR. The Analytical Proteomics Laboratory, which combines activities of the Mass Spectrometry Lab and BRSL to create a collaborative environment for protein handling, protein mass spectrometry, and bioinformatics, is in the Shankel Structural Biology Center. In the same building, the High Throughput Screening Laboratory has integrated and automated robotics equipment for carrying out biochemical and cell-based assays and a chemical library of more than 100,000 compounds with diverse structures and drug-like properties for biological screening. The service laboratories have professional staff that provides training in specialized research techniques in addition to their service functions.

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