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Department of Medicinal Chemistry

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Principal Course Distribution Requirement

Principal courses offer introductions to the breadth of disciplines in the College. They acquaint students with the subject matter in an area, with the types of questions that are asked about that subject matter, with the knowledge that has been developed and is now basic to the area, and with the methods and standards by which claims to truth are judged.

Students must complete courses in topical groups in three major divisions (humanities, natural sciences and mathematics, and social sciences). For the B.A., three courses are required from each division, with no more than one course from any topical group. The B.G.S. requires two courses from each division, with no more than one from any topical group. To fulfill the requirement, a course must be designated as a principal course according to the codes listed below.

These are the major divisions, their topical subgroups, and the codes that identify them:

Humanities

  • HT: Historical studies
  • HL: Literature and the arts
  • HR: Philosophy and religion

Natural Sciences and Mathematics

  • NB: Biological sciences
  • NE: Earth sciences
  • NM: Mathematical sciences
  • NP: Physical science

Social Sciences

  • SC: Culture and society
  • SI: Individual behavior
  • SF: Public affairs

No course may fulfill both a principal course distribution requirement and a non-Western culture or second-level mathematics course requirement. Laboratory science courses designated as principal courses may fulfill both the laboratory science requirement and one of the distribution requirements. No free-standing laboratory course may by itself fulfill either the laboratory science requirement or a principal course requirement. Students should begin taking principal courses early in their academic careers. An honors equivalent of a principal course may fulfill a principal course requirement.

View all approved principal course distribution courses »

Non-Western Culture Requirement

A non-Western culture course acquaints students with the culture, society, and values of a non-Western people, for example, from Asia, the Pacific Islands, the Middle East, or Africa. Students must complete one approved non-Western culture course.

One approved non-Western culture course is required. Occasionally courses with varying topics fulfill the non-Western culture course requirement. See the Schedule of Classes for details. These courses are coded NW.

View all approved non-Western culture courses »

Transfer and Earned Credit Course Codes

These codes are used to evaluate transfer credit and to determine which academic requirements a course meets.

  • H: Humanities
  • N: Natural Sciences and Mathematics
  • S: Social Sciences
  • W: World Civilization and Culture
  • U: Undesignated Elective Credit (course does not satisfy distribution requirement)

All Medicinal Chemistry courses

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A study of the biochemical principles of macromolecular structure and function, molecular communication, and the metabolism of nutrients and xenobiotics as applied to problems of medicinal and pharmacological significance. Prerequisite: Concurrent enrollment in MDCM 602 Lab. LEC
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Laboratory exercises illustrating the application of chemical principles to biochemical processes of medicinal, pharmacological, and clinical significance. Prerequisite: Concurrent enrollment in MDCM 601. LAB
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A study of the biochemical principles of macromolecular structure and function, biosynthesis, molecular communication, and the metabolism of nutrients and xenobiotics as applied to problems of medicinal and pharmacological significance. Prerequisite: MDCM 601. LEC
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This course will acquaint the pharmacy students with the current status of botanical use in the United States. A basic foundation will be provided so that the pharmacist can properly assess the appropriateness and usefulness of various phytomedicines and combinations in managing certain ailments with regard to efficacy, safety, potential toxicity, and potential herb-drug interactions. Prerequisite: MDCM 626 or instructor permission. LEC
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The course will provide a technical background for understanding the scientific basis underlying the use of herbal medicines. This will be followed by practical information about the pharmacological and chemical properties as well as clinical uses of herbal medicines. Active student participation in discussing the properties of these non-prescription medicinals is expected. Prerequisite: MDCM 601. LEC
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A study, from the molecular viewpoint, of the organic substances used as medicinal agents, including consideration of their origins, chemical properties, structure-activity relationships, metabolism and mechanisms of action; this course emphasizes drugs affecting the central nervous system. Prerequisite: CHEM 626 and MDCM 601. LEC
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A continuation of MDCM 625 with emphasis on autonomic and cardiovascular agents and peripherally-acting hormones. Prerequisite: MDCM 625. LEC
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A continuation of MDCM 625 and MDCM 626 with special emphasis on anticancer, antiviral, antibacterial, antifungal and non-steroidal anti-inflammatory drugs. Prerequisite: MDCM 625. LEC
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A discussion of the principles of contemporary drug design with specific examples chosen from the original literature. Prodrugs: bioisosteres; modulation of drug absorption, distribution, metabolism, and excretion; molecular dissection; rigid analogs; pharmacophores; etc., will be treated. Prerequisite: MDCM 627. LEC
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Research in medicinal chemistry. Students will be assigned to a laboratory research problem. Prerequisite: Consent of instructor. IND
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A lecture course designed to acquaint beginning research students with basic laboratory techniques, principles of laboratory safety, use of instrumental methods for structure elucidation, and the writing of scientific reports. Prerequisite: Consent of instructor. LEC
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This course encompasses original work on a laboratory problem of limited scope, honors reading assignments from medicinal chemistry literature, or in-depth discussions of assigned topics. Prerequisite: Consent of instructor. IND
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A study of the principles of macromolecular structure and function, biosignaling, bioenergetics and metabolism, with an emphasis on the relationship between biochemistry and medicine. Prerequisite: Graduate standing or permission of instructor. LEC
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A study of the principles of basic enzymology, including chemical reactions, biosynthesis, and metabolism. In addition, the course will cover lipids, hormones, vitamins, and minerals. Prerequisite: Graduate standing or permission of instructor. LEC
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The goal of this one-credit-hour course is to provide an overview of physiological mechanisms and disease processes as a background for intermediate level courses in medicinal chemistry, drug discovery and drug development. Prerequisite: One college-level course in biology. LEC
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An overview of the field of medicinal chemistry, including discussions of research techniques and the application of organic chemistry to medicinal chemistry problems. Prerequisite: Graduate standing or permission of instructor. LEC
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The discovery and properties of pharmaceutical agents, including a survey of the various drug classes important in clinical applications. The relationship between chemical structure and biological mechanism of action will be emphasized. Prerequisite: Graduate standing or permission of instructor. LEC
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A study, from the molecular viewpoint, of the organic substances used as medicinal agents, including consideration of their origins, chemical properties, structure-activity relationships, metabolism and mechanisms of action; this course emphasizes drugs affecting the central nervous system. Prerequisite: CHEM 626 and MDCM 621. LEC
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A continuation of MDCM 725 with emphasis on autonomic and cardiovascular agents and peripherally-acting hormones. Prerequisite: MDCM 725. LEC
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A continuation of MDCM 725 and MDCM 726 with special emphasis on anticancer, antiviral, antibacterial, antifungal and non-steroidal anti-inflammatory drugs. Prerequisite: MDCM 725. LEC
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Experimental approaches to understanding mechanism of drug action. Use of drugs as tools to understand functioning of biological systems will also be stressed. Historically important experiments will be discussed along with experiments which are currently used to define drug mechanisms. Topics will include: dose-response, drug receptors, drug metabolism, chemotherapy as well as autonomic CNS, cardiovascular and renal pharmacology. (Same as P&TX 742.) Prerequisite: BIOL 600 and BIOL 646 or equivalent, or consent of instructor. LEC
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An introductory graduate level course in bioorganic and medicinal chemistry, in which the principles of organic reaction mechanisms in biological systems are discussed. This course discusses the organic chemistry of metabolic transformations of biomolecules and their associated cofactors, both organic coenzymes and metal ions. LEC
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A detailed study of the molecular aspects of nerve transmission will be covered with special emphasis on the uptake, storage, release, biosynthesis, and metabolism of specific neurotransmitters. Drugs affecting these processes and current research on receptor isolation and receptor mechanisms will be discussed from a chemical viewpoint. (Same as BIOL 775, CHEM 775, NURO 775, P&TX 775, and PHCH 775.) Prerequisite: Consent of instructor. LEC
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A laboratory course designed to acquaint advanced undergraduate and beginning graduate students with laboratory safety, the research notebook, use of advanced instrumental techniques for structural assignment and verification, methods of separation and purification, and the use of advanced reagents and laboratory transformations relevant to research in medicinal chemistry. Prerequisite: Consent of instructor. LAB
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A discussion of bioassay-directed screening, the isolation, structure determination, biosynthesis, partial synthesis and total chemical synthesis of organic natural products of medicinal significance. Examples of the classes of compounds to be considered include steroid hormones, cardiac glycosides, alkaloids, antibiotics, terpenes, and the like. Prerequisite: Graduate standing or consent of instructor. LEC
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A discussion of the principles of contemporary drug design with specific examples chosen from the original literature. Prodrugs; bioisosteres; Kcat inhibitors; active site directed reversible and irreversible inhibitors; quantitative SAR; modulation of drug absorption, distribution, metabolism and excretion; molecular dissection; rigid analogs; pharmacophores; etc., will be treated. Prerequisite: Graduate standing or completion of MDCM 624 and MDCM 627. LEC
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An introduction to the chemical and biochemical principles which govern the interaction of drugs and chemicals with cells and organisms. Topics include absorption, distribution, metabolism, and excretion; passive vs. active processes; pharmacokinetics; bioactivation vs. detoxication; and applications in drug design and improvement. Prerequisite: One year of organic chemistry and one course in biochemistry. LEC
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A discussion of the principles of contemporary drug design with specific examples chosen from the original literature. Drug-like properties; conformational constraint; structure-based drug design; library generation; HTS hit optimization, will be treated. LEC
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Reports by research students and discussions of developments in the field not covered in formal courses. LEC
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Lectures and discussion on ethical issues in the conduct of a scientific career, with emphasis in the conduct of a scientific career, with emphasis on practical topics of special importance in molecular-level research in the chemical, biological, and pharmaceutical sciences. Topics will include the nature of ethics, the scientists in the laboratory, the scientist as author, grantee, reviewer, employer/employee, teacher, student, and citizen. Discussions will focus on case histories. Graded on a satisfactory/unsatisfactory basis. (Same as MDCM 801, NURO 801, P&TX 801, PHCH 801 and PHCH 802.) LEC
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The course will cover basic techniques of moral reasoning, especially as applied to ethical issues in the physical sciences and engineering. Topics covered will include the ethical conduct of research, the federal and professional guidelines for different kinds of research, and the ethical dimensions of publication and professional life. Emphasis will be on practical applications, cases and student involvement. (Same as GS 804, NURO 804, P&TX 804, and PHCH 804.) Prerequisite: Must be admitted to the program or division of Pharmacy to enroll in this class. LEC
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An in-depth examination of the pathways, enzymes, and mechanisms of xenobiotic biotransformation in a combined lecture-readings-discussion format. Emphasis will be on recent as well as classic methods of findings. Prerequisite: MDCM 790 or MDCM 791 or consent of instructor. LEC
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A laboratory course exemplifying various techniques used in studying the metabolism of foreign organic compounds in mammalian systems. In addition, enzymatic reactions in other plant and microbial systems are studied. Prerequisite: Consent of instructor. LAB
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Hours and credit to be arranged. RSH
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Hours and credit to be arranged. Independent investigation of a research problem of limited scope. Prerequisite: Consent of instructor. THE
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An in-depth discussion of topics of current interest to medicinal chemists. Prerequisite: Consent of instructor. LEC
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Theory and practice of contemporary molecular modeling: real-time computer graphics, model-building routines, use of structural databases, molecular mechanics and molecular dynamics calculations. The laboratory section places emphasis on drug design; work on own problems is welcome. (Same as BIOL 952.) Prerequisite: Graduate standing or consent of instructor. LAB
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Preparation of an original research proposal concerning contemporary problems in medicinal chemistry. Prerequisite: Consent of instructor. LAB
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Advanced level research in collaboration with a faculty member, which may involve projects in one or more of the following areas: organic synthesis, isolation and structure elucidation, metabolism, biochemical mechanisms of drug action. Prerequisite: Doctoral degree or equivalent in an appropriate related area, and consent of instructor. RSH
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Hours and credit to be arranged. Original chemical research in the synthesis and development of medicinal agents, elucidation of the chemical mechanisms of drug action, drug metabolism, and drug toxicities. THE
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