Analytical Method Development
- GC, HPLC (reverse phase, ion exchange, size exclusion) method development
- Bioanalytical method development (HPLC with UV, fluorescence or mass detection)
- Stability indicating assays
- Electrophoresis
- Capillary electrophoresis
Oral Solid Dosage Forms
- Compressed tablets: immediate, extended and controlled drug delivery; direct compression; wet granulation; instrumented tablet press
- Modified release tablets: matrix tablets; coated tablets (film, sustained release and enteric)
- Chewable tablets
- USP drug disintegration and dissolution studies
- Multiparticulate dosage forms (extrusion/spheronization): immediate and extended and controlled drug delivery
Oral Liquid Dosage Forms
Oral liquids
- Oral suspensions
- Oral emulsion
- Oral reconstituted powders
Transdermal Drug Delivery
- Creams
- Ointments
- Suppositories
Physical Testing
- Tablet hardness
- Tablet friability
- Weight uniformity
- Loss on drying
- Particle size analysis (mm to nm)
Drug Substance and Drug Product Stability
- pH-degradation rate profiling
- Accelerated stability testing
In Vivo Screening
- Small animal pharmacokinetics
- Small animal pharmacodynamics
- Pharmacokinetics/ Pharmacodynamics modeling
- Bioavailability studies
- Toxicity studies
- Efficacy evaluations in animal models
- Prodrug conversion studies
- Small animal imaging studies
- Plasma protein binding determination
Synthesis
- Prodrug design and synthesis
- Drug synthesis (mg to multigram scale)
- Reference standard preparation
- Peptide synthesis (mg to gram scale)
